Grant opportunity · PAR-25-211
Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)
Who can apply (as listed)
- Native American tribal organizations (other than federally recognized governments)
- Native American tribal governments (federally recognized)
- Public housing authorities / Indian housing authorities
- City or township governments
- Special district governments
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Others (see the opportunity text)
- County governments
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- State governments
- Independent school districts
- Private institutions of higher education
- Public and state-controlled institutions of higher education
- Small businesses
- For-profit organizations (other than small businesses)
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions using a milestone-driven, biphasic award mechanism, R61/R33 Phased Innovation Award. Specifically, this NOFO solicits applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. The first phase, funded by the R61, will providing for up to 2 years to identify unique host biological patterns (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with heterogeneity of probiotic clinical effects using observational or s…
Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.
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