Grant opportunity · PAR-25-210
Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
Who can apply (as listed)
- Private institutions of higher education
- County governments
- Native American tribal governments (federally recognized)
- City or township governments
- Independent school districts
- Public housing authorities / Indian housing authorities
- Small businesses
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- State governments
- Native American tribal organizations (other than federally recognized governments)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Public and state-controlled institutions of higher education
- Special district governments
- Others (see the opportunity text)
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovat…
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