Grant opportunity · PAR-25-145
Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)
Who can apply (as listed)
- For-profit organizations (other than small businesses)
- Special district governments
- Small businesses
- Native American tribal organizations (other than federally recognized governments)
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Others (see the opportunity text)
- Independent school districts
- City or township governments
- Public and state-controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- State governments
- County governments
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- Native American tribal governments (federally recognized)
- Private institutions of higher education
The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints (biomarkers, imaging, patient-reported outcomes, or combined elements) for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae.
Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.
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