Grant opportunity · PAR-25-037
Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)
Who can apply (as listed)
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Native American tribal organizations (other than federally recognized governments)
- Special district governments
- Public housing authorities / Indian housing authorities
- City or township governments
- State governments
- County governments
- Native American tribal governments (federally recognized)
- Independent school districts
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- Small businesses
- Private institutions of higher education
- Public and state-controlled institutions of higher education
- For-profit organizations (other than small businesses)
- Others (see the opportunity text)
This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact…
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