Grant opportunity · PAR-25-269
NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)
Who can apply (as listed)
- County governments
- Public housing authorities / Indian housing authorities
- State governments
- City or township governments
- Private institutions of higher education
- Others (see the opportunity text)
- Special district governments
- Independent school districts
- Native American tribal organizations (other than federally recognized governments)
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Small businesses
- Public and state-controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, probiotics, and products marketed as dietary supplements), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to three years (R61 phase) of support for milestone-driven testing of pharmacokinetics, bioavailability, and assessment of the natural products effect (i.e., measure of mechanism of action) wh…
Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.
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