Grant opportunity · PAR-25-270
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)
Who can apply (as listed)
- Public housing authorities / Indian housing authorities
- Others (see the opportunity text)
- Small businesses
- State governments
- Special district governments
- City or township governments
- Native American tribal organizations (other than federally recognized governments)
- Private institutions of higher education
- Public and state-controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- County governments
- Independent school districts
- For-profit organizations (other than small businesses)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to 3 years support for studies to replicate the impact of the natural product on target engagement when used by humans, and assess whether there is an association between the degree of the impact on target engagem…
Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.
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