Grant opportunity · PAR-25-271
NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)
Who can apply (as listed)
- Others (see the opportunity text)
- Small businesses
- Public housing authorities / Indian housing authorities
- County governments
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Special district governments
- Independent school districts
- Native American tribal governments (federally recognized)
- State governments
- City or township governments
- Native American tribal organizations (other than federally recognized governments)
- Public and state-controlled institutions of higher education
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Private institutions of higher education
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural product produces a reproducible and measurable impact on target engagement (i.e., measure of the mechanism of action). Only in cases when it is not possible/practical to measure target engagement in the patient population of interest or when there is a fundamental understanding of the products mech…
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