Grant opportunity · PAR-25-325
Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)
Who can apply (as listed)
- Independent school districts
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- City or township governments
- Private institutions of higher education
- Public and state-controlled institutions of higher education
- Others (see the opportunity text)
- For-profit organizations (other than small businesses)
- Special district governments
- Public housing authorities / Indian housing authorities
- Native American tribal organizations (other than federally recognized governments)
- Small businesses
- State governments
- County governments
- Native American tribal governments (federally recognized)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to support extramural research to investigate and mitigate challenges facing clinical assay development and subsequent analytical validation due to preanalytical variability in tumor tissue biopsies, blood biospecimens utilized as liquid biopsies", or other biospecimens as described in this NOFO. Extramural research funded under this NOFO may include investigations of preanalytical variability associated with the procurement and study of small biopsies (core biopsies, small excision samples), blood utilized for "liquid biopsies", tissue swabs, tissue secretions, pleural and esophageal aspirates, feces, or bodily fluids like sweat, urine, CSF, breast milk and saliva. Investigator-designed experiments will explore how different biospecimen preanalytical conditions affect emerging and clinically relevant biomarkers quantified by a variety of testing platforms. The results from this research pro…
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