GrantSet

Grant opportunity · PAR-25-446

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Applications close753 days leftAug 21, 2028
AgencyNational Institutes of Health
CategoryDiscretionary
Assistance listing93.279
OpensSep 10, 2025
ClosesAug 21, 2028
Award floor
Award ceiling$3,000,000
Expected awardsNot stated

Who can apply (as listed)

  • City or township governments
  • Native American tribal governments (federally recognized)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education)
  • Native American tribal organizations (other than federally recognized governments)
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Independent school districts
  • Nonprofits without 501(c)(3) status (other than institutions of higher education)
  • Others (see the opportunity text)
  • Special district governments
  • Public housing authorities / Indian housing authorities
  • For-profit organizations (other than small businesses)
  • Small businesses
  • County governments
  • State governments
From the listing

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.

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