Grant opportunity · PAR-25-447
NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)
Who can apply (as listed)
- Private institutions of higher education
- For-profit organizations (other than small businesses)
- Special district governments
- Small businesses
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- Native American tribal governments (federally recognized)
- County governments
- State governments
- City or township governments
- Public and state-controlled institutions of higher education
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Native American tribal organizations (other than federally recognized governments)
- Others (see the opportunity text)
- Public housing authorities / Indian housing authorities
- Independent school districts
This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine
Excerpt as published. The full synopsis, required forms, and any amendments are on the official listing.
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